ABSTRACT Ilaprazole is a Proton Pump Inhibitor (PPI), an anti-acidic drugused in the treatment of dyspepsia, peptic and duodenal ulcer disease, gastroesophageal reflux disease (GERD).Ilaprazole at oral doses of 10 mg has shown higher suppression of gastric acid secretion and more prolonged plasma half-life, and similar safety compared to 20 mg omeprazole. Elimination half-life for Ilaprazole ranged from 4.7 to 5.3 h, Administration of Ilaprazole in an extended-release dosage form would be more desirable by maintaining the plasma drug concentrations at a prolonged period of time. It will be more beneficial in maintaining nocturnal gastric pH<4. The main objective to formulate and evaluate extended-release matrix tablets of Ilaprazole by wet granulation technique by using natural polymers and synthetic polymers. The granules were evaluated by angle of repose, Bulk and Tapped density, Hausner’s ratio, Carr’s index. The tablets were subjected to Thickness, Weight variation, Drug content, Hardness, Friability and In-vitro drug release studies. The Physicochemical properties of tablets were found within the limits. In-vitro dissolution study was carried out for first 2 hrs in 0.1N Hcl and remaining 10 hrs in 6.8 PH Phosphate buffer as a dissolution medium. Based on the results F-21 (Drug: Eudragit RSPO ratio 1:2) formulation was chosen as a best among all the formulations in the point of drug release and mechanism. The release mechanisms were explored and explained with Zero order, First order, Higuchi, Peppas. Keywords: Ilaprazole, wet granulation technique, Eudragit RSPO, Zero-order Kinetics