The data provided refer to our published article: T. John, J. Adler, C. Elsner, J. Petzold, M. Krueger, L.L. Martin, D. Huster, H.J. Risselada, B. Abel, Mechanistic insights into the size-dependent effects of nanoparticles on inhibiting and accelerating amyloid fibril formation, J. Colloid Interface Sci. 622 (2022), 804–818. https://doi.org/10.1016/j.jcis.2022.04.134 This article is accompanied by a 'Data in Brief' article that explains in more detail the use of the curvature model and our molecular dynamics (MD) simulations: T. John, L.L. Martin, H.J. Risselada, B. Abel, Curvature model for nanoparticle size effects on peptide fibril stability and molecular dynamics simulation data, Data Brief 45 (2022), 108598. https://doi.org/10.1016/j.dib.2022.108598