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ABSTRACT Egg donation is a form of assisted reproductive technology used to help women with infertility. Though egg donation might attract some material benefit, potential egg donors often do not have knowledge of the associated health risks. This study investigated the knowledge of female undergraduates in Kwara State, north-central Nigeria, about oocyte donation to infertile couples. It was a descriptive cross-sectional study carried out in 2018 involving 559 female undergraduates recruited through a multi-stage sampling technique. An adapted questionnaire validated and tested for reliability was used for data collection. Data were analyzed using IBM SPSS version 25 software. Descriptive statistics of frequency count and percentages were used to answer research questions and Chi-square was employed to test the hypotheses at a <0.05 level of significance. Majority of the respondents were 15-20 years old (66.3%, 371) unmarried (96.8%, 541), Muslims (60.5%, 338), Yoruba (82.8%, 463), first-year students (54.4%, 304). Most of the respondents had poor knowledge of oocyte donation (60.3%, 337); poor knowledge of oocyte donation procedure (69.9%, 391), and poor knowledge of the health risks associated with oocyte donation (65.5%, 366). The study revealed that female undergraduates in the study area have poor knowledge of oocyte donation, its procedure, and the attendant health consequences. Universities in the study area should include oocyte donation as a topic in General Studies (GNS) in order to equip students with adequate information on the potential benefits and drawbacks of oocyte donation.