Organic Division, Chemistry Department, Banaras Hindu University, Varanasi-5 Manuscript received 1 November 1971; accepted 29 April 1975 In view of the encouraging results shown by a number of bis-benzimidazole-2-sulphonamido derivatives as hypoglycemic agents (under communication), a series of compounds namely p-­toluenesulphonyl derivatives of N,N'-bis-(4-quinolino/4-quinaldino/4-quinazolino and 9-acridino) polymethylene diamines have been prepared and screened for their hypoglycemic activity. Some of the compounds showed significant blood sugar lowering activity in rats.