The physical properties, characterization, and uses of polymorphism are highlighted in this article. Polymorphism is important in pharmaceutical compounds and it's important to research and development of drug and drug discovery. Polymorphism in pharmacological substances is well known for its prevalence and relevance. During medication discovery and development, it is critical to plan and pick the appropriate form from the start. This review introduces the basic concepts of Polymorphism in pharmaceutical compounds and also vibrational spectroscopy in polymorphism applications and study of crystal polymorphism, cocrystals, physicochemical characteristics and uses, polymorphism research methods, Chemical stability and polymorphism, polymorphisms effect on drug substance and drug administration product polymorphism's impact on bioavailability, solubility, and dissolution bioequivalence (BA) and bioequivalence (BE) polymorphism's impact on drug product manufacturing, etc. Hence this study topic is undertaken for detail insights of phenomena of polymorphism and its relevance in drug development process. Key words: Polymorphism, Crystallization, Bioavilability ,API, Polymorph.