Endoscopic ultrasound (EUS) is a method of exploration of the digestive system that combines two techniques: endoscopy and ultrasound. EUS has several applications in digestive pathology. Echo-endoscopic biopsy (EEB) of pancreatic masses is a technique that allows fine needle aspiration to obtain material for cytohistological analysis. It is indicated each time a histological examination can have a diagnostic and/or therapeutic interest.For that we realized a retrospective study between January 2017 and December 2020. All patients referred to the department for a bilio-pancreatic echo-endoscopy in the framework of a pancreatic tumor were included in the study. We collected 90 patients who met our inclusion criteria. We recorded the patients demographics, pathologic history, symptoms, and ultrasound, CT, and EUS. During the echo-endoscopic examination, we always tried to specify some essential data according to the international recommendations, depending on the pathology (benign or malignant).