Multidrug-resistant Tuberculosis (MDR-TB) is a type of Tuberculosis (TB) that is resistant to at least one or more of the main anti-TB drugs, namely Rifampin or Isoniazid, so this infection is more difficult to eliminate. Good knowledge and behavior of caregivers and patients can affect the success of treatment because they tend not to be late in taking treatment. In this data note we provide the details of a research database of 228 MDR-TB caregivers and patients underwent treatment from January 2020 to December 2021 in preferred hospital in West Java, Indonesia. The purposes of this publication are to describe the dataset for external researchers who may be interested in making use of it, and to detail the methods used to obtain the dataset to determine the level of knowledge and behavior of MDR-TB caregivers and patients regarding the disease through a validated questionnaire consisted of the knowledge and behavior distributed to respondents via online and offline.