We performed comprehensive epigenetic profiling in immune cell samples from patients with ankylosing spondylitis and healthy controls. We used ChromHMM to integrate epigenomic data. ChromHMM filenames are in the format ChromHMM_sampleID_celltype_n.bed.gz where n is the number of states in the ChromHMM emission model. We performed Capture-C to detect chromosome looping interactions between gene promoters and SNPs associated with ankylosing spondylitis. Capture-C count data are shown in the format: CaptureC_celltype_gene_Pro/SNP_normalised.unionbdg We used PeakY to calculate a score for each interaction. PeakY scores are given in the following format: PeakY_AS/HV_celltype_tier_chrloc_gene_Pro/SNP.txt gene_Pro and gene_SNP relate to the baitsets given in Table S8.