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Claim

Tissue-specific downregulation of fatty acid synthase sup-presses intestinal adenoma formation via coordinated repro-graming of transcriptome and metabolism in the mouse model of Apc-driven colorectal cancer

descriptionPublicationkeyboard_double_arrow_right Article 18 Mar 2022 English Publisher:Zenodo
Authors: Drury, James; Young, Lindsay EA; Scott, Timothy L; Kelson, Courtney O; He, Daheng; Liu, Jinpeng; Wu, Yuanyan; +6 Authors

doi: 10.5281/zenodo.6369222 , 10.5281/zenodo.6369223

Tissue-specific downregulation of fatty acid synthase sup-presses intestinal adenoma formation via coordinated repro-graming of transcriptome and metabolism in the mouse model of Apc-driven colorectal cancer

Abstract

Figure S1: Characterization of transgenic mouse models; Figure S2: Triglyceride levels in tissue and plasma from transgenic mice; Figure S3: Heterozygous and homozygous deletion of FASN in Apc/Cre mice is associated with an increase in citrate synthase expression; Table S1A: Samples for RNA-Seq analysis and RNA-Seq coverage summary; Table S1B: Complete report for RNA-Seq analysis; Table S1C: Transcriptome changes in (1) FASND/-/Apc/Cre vs Apc/Cre mice and (2) FASND/D/Apc/Cre vs Apc/Cre mice; Table S1D: Gene set enrichment analysis for (1) Apc/Cre vs FASN+/D/Apc/Cre (negative), (2) Apc/Cre vs FASN+/D/Apc/Cre (positive), (3) Apc/Cre vs FASND/D/Apc/Cre mice (negative), and (4) Apc/Cre vs FASND/D/Apc/Cre mice (positive); Table S2: Lipid analysis for (A) Diglycerides (DAGs) in mouse adenomas, (B) Free fatty acids (FFAs) in plasma, (C) Free fatty acids (FFAs) in mouse adenomas, and (D) Sphingolipids in mouse adenomas; Table S3: RPPA analysis of metabolic enzymes. Uncut gels.

Uncut gels are provided in 2022_03_22_notebook_65414.4.pdf

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Keywords

colorectal cancer; fatty acid synthase; lipid metabolism; colorectal cancer initiation; APC mutation

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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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