Supplementary material - A data science approach for the identification of molecular signatures of aggressive cancers. Supplementary Table 1: List of R dependency packages. Supplementary Table 2: Gene members of each pathway listed from the literature and extracted from KEGG, Biocarta, and Reactome databases. Supplementary Table 3: Gene members with their number of connections, frequency of overexpression, sample number, normalized counts, and normalized connections. Supplementary Table 4: Genes with their normalized connections per type of cancer and aggressivity.. Supplementary Table 5: Mean, Std. deviation, and variance of normalized counts from target target genes between H and L classes. Supplementary Table 6: Genes that are specific to each cancer classe. Supplementary Table 7: Sub interactome of proteins corresponding to the genes of Tables 3 and 4 (except H2AFZ and TMEFF2 ) as well as Figure 5. Supplementary Table 8: Kruskal-Wallis test by pathway. Supplementary Table 9: Wilcoxon test of cancer types per pathway. Supplementary Table 10: Correlations between entropies, PC1, and PC2. Supplementary Table 11: Percentage of contribution for up-regulated genes to the PCA���s first, second, and third components. Supplementary Table 12: Gene importance as defined by RFC.