The ongoing COVID-19 pandemic has been widely alleged to be the highest health crisis in many decades. In response to the widespread disease, the World Health Organization and various world governments instituted evidence-based preventive measures to control the rapid spread of the coronavirus. Consequently, there are indications of negligence and deliberate disregard of these measures by most individuals. The present study examined type A behavioral pattern as a personality disposition that could account for the variance in compliance to the COVID-19 safety protocols. A convenience sample of four hundred and forty-eight respondents pooled from different locations in Enugu and Ebonyi states, Nigeria, participated in the study. The result of the simple regression analysis confirmed the hypothesis of the study. Thus, it was concluded that TABP is a significant predictor of compliance to the safety protocols relative to the COVID-19 pandemic. The result provided valuable data for managing the spread of infectious diseases.