1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

descriptionPublicationkeyboard_double_arrow_right Article 20 Aug 2021 English Publisher:American Chemical Society (ACS)Journal:Journal of Medicinal Chemistry, volume 64, pages 12,790-12,807 (issn: 0022-2623, eissn: 1520-4804,

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Authors: Lutete Peguy Khonde; Rudolf Müller; Grant A. Boyle; Virsinha Reddy; Aloysius T. Nchinda; Charles J. Eyermann; Stephen Fienberg; +17 Authors

doi: 10.1021/acs.jmedchem.1c00837 , 10.5281/zenodo.6352683 , 10.5281/zenodo.6352682

pmid: 34414766

pmc: PMC10500703

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

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Abstract

This is the accepted manuscript version of the work published in its final form as Khonde, Lutete Peguy; Müller, Rudolf; Boyle, Grant A.; Reddy, Virsinha; Nchinda, Aloysius T.; Eyermann, Charles J.; Fienberg, Stephen; Singh, Vinayak; Myrick, Alissa; Abay, Efrem; Njoroge, Mathew; Lawrence, Nina; Su, Qin; Myers, Timothy G.; Boshoff, Helena I. M.; Barry, Clifton E.; Sirgel, Frederick A.; van Helden, Paul D.; Massoudi, Lisa M.; Robertson, Gregory T.; Lenaerts, Anne J.; Basarab, Gregory S.; Ghorpade, Sandeep R.; Chibale, Kelly. Journal of Medicinal Chemistry Volume: 64 issue: 17, page(s): 12790–12807. https://doi.org/10.1021/acs.jmedchem.1c00837 Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing help@openaccessbutton.org.

Related Organizations

National Institutes of Health
United States
National Institute of Allergy and Infectious Diseases
United States
National Institute of Health
Pakistan
National Institute of Health (NIH/NICHD)
United States
South African Medical Research Council
South Africa

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Keywords

Models, Molecular, Sulfonamides, Molecular Structure, Antitubercular Agents, Hep G2 Cells, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Structure-Activity Relationship, Cell Wall, Drug Discovery, Humans

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