Positron Emission Tomography - Computed Tomography (PET-CT) has been used to diagnose malignancy before surgery. However, there may be an increase in 18F-fluorodeoxyglucose (FDG) uptake in PET scans in benign conditions, leading to a false-positive diagnosis of malignancy and unnecessary surgery. This PET-CT investigation is expensive and is not without risk, including radiation and drug or contrast hypersensitivity. Although variable uterine uptakes of FDG activities in PET-CT had been reported in the literature, unawareness of its possibility in benign conditions could lead to a false alarm of malignancy. This paper reported a patient with a false-positive FDG finding presenting as a malignant uterine lesion for surgery, aiming to raise the clinical awareness of this finding.