This is the dataset accompanying the manuscript: "Computational Analysis of Cortical Neuronal Excitotoxicity in a Large Animal Model of Neonatal Brain Injury" Panagiotis Kratimenos1,2,5 *, Abhya Vij5, Robinson Vidva6, Ioannis Koutroulis3,4,5, Maria Delivoria-Papadopoulos7**, Vittorio Gallo1,5, and Aaron Sathyanesan1,5* 1Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital, Washington DC, USA 2Department of Pediatrics, Division of Neonatology, Children’s National Hospital, Washington DC, USA 3Department of Pediatrics, Division of Emergency Medicine, Children’s National Hospital, Washington, DC, USA 4Center for Genetic Medicine Research, Children’s National Research Institute and Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA 5George Washington University School of Medicine and Health Sciences, Washington DC, USA 6Digirobi Solutions, Bengaluru, Karnataka, India 7Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA *Corresponding Authors: Panagiotis Kratimenos, MD, PhD: panagiotis.kratimenos@childrensnational.org Aaron Sathyanesan, PhD: asathyanesan@childrensnational.org 111 Michigan Avenue, Washington, DC, 20010, USA