Over the years, entrepreneurship has assumed a ubiquitous part of the business ecosystem. Perhaps, it contributes positively to national economies and has been widely considered among the primary engines of economic growth and job creation. Thus, understanding the possible determinants of the variation in entrepreneurial motivation among the youth is vital for helping the government and policy-makers adopt adequate measures to support the creation and development of new ventures. In recent years, the turbulent economic realities in Nigeria dominated by financial criseshave affected entrepreneurship development. Thus, this paper investigated the effect of rising inflation on entrepreneurial motivation among youths in southeast Nigeria. A convenience sample of three hundred and twenty-two undergraduates pooled from five tertiary institutions in the southeast participated in the study. The study results underscored rising inflation in the country as a significant macroeconomic determinant of entrepreneurial motivation among the youths.