Introduction: Haemoglobin is the red colour pigment present inside RBC. All the blood components are derived from the haematopoietic stem cells of the same bone marrow. Factors affecting the bone marrow also affects all the cells including the haemoglobin level and the platelet count. Less is known on the relationship between low or high level of haemoglobin on platelet count. This work was therefore carried out to determine this relationship. Materials And Methods: The study was done in Dept. of Physiology, Jorhat Medical College. Study population included 100 undergraduate medical students of age 18-25 years . Haemoglobin Estimation & Platelet Count will be measured by ACCUREX ACCULAB CBC 360+ HEMATOLOGY Analyser Machine. Ethical Clearance was obtained from Institutional Ethical Committee (H), Jorhat Medical College, Jorhat. Students unpaired t- test was used to compare the mean values of study variables and other parameters in relation to the study. The P value <0.05 was considered as significant. Results: We found that mean Hb count is 10.91±1.05 and 10.22±0.83 respectively when platelet count in between 1.5- 2.5 lakhs/mm3 and >2.5 lakhs/mm3. Mean Platelet count came 2.59±0.58 lakhs/mm3 and 1.89±0.62 respectively when Hb between 9 – 11 gm/dl and >11 gm/dl. Conclusion: The reason for the relationship between low and high platelet count on hemoglobin level may be linked to the normal physiology of hematopoiesis where the origin of all blood components occurs in the bone marrow. This leaves scope for further research to use in therapy like Plateletpheresis where lower hemoglobin concentrations meant higher platelet yield and vice versa.