Menopause is most significant event for a woman life, carrying with it a slew of physiological changes with long-term consequences for her life. Although is transition to menopause has uncertain physiology and clinical symptoms. There are suggested there are causal relationships between menopause and a variety of manifestations and disorders. The proof for these links is changed and examined. There have been numerous theories about the symptoms that arise before, during, and after menopause. Hormone Replacement Therapy (HRT) is frequently used to treat symptoms of estrogen withdrawal, including dyspareunia, hot flushes, vaginal dryness, night sweats, insomnia, however, it has not been demonstrated to help with depression or arthritis in middle age. Hormone replacement therapy doses and routes differ depending on the indication. Hormone replacement therapy complications vary depending on the regimen utilized. This article will describe these symptoms, as well as the underlying pathophysiology and treatment alternatives.