Arthritis is a chronic, inflammatory, systemic autoimmune disorder. It is an inflammation of synovial joint due to immune mediated response.[3] One fifth of the world���s elderly suffer with arthritis .In the anti-arthritic activity the production of auto antigen in certain arthritic disease may be dueto denaturation of protein, membrane lysis and proteinase action. The mechanism of denaturation probably involves electrostatic hydrogen,hydrophobic and disulphide bonding. Anti denaturation study which includes the albumin denaturation is performed by usingBovine serum albumin (BSA). When BSA is heated it undergoes denaturation and express antigens associated with type 3 hypersensitivity reactions and that is related to diseases such asserum sickness, glomerulonephritis, rheumatic arthritis, and lupus erythromotosus. Key words: Inflamatory,Arthritis,Medical response,Lysis