Orally disintegrating tablets (ODTs) are tablets with medicinal substances, which can rapidly disintegrate or dissolve in the oral cavity without using water. Their salient immediate release property in many ways make the ODT a popular oral dosage form in special circumstances and situations such as institutionalized patients, travelling patients and patients with swallowing challenges. Mouth disintegrating tablets are also known as Fast melting tablets, Orodispersible tablets, fast dissolving/dispersing tablets or melt in mouth tablets. This article reviews the potential benefits offered by MDTs as an oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Products of ODT technologies entered the market in the 1980s, have grown steadily in demand, and their product pipelines are rapidly expanding. New ODT technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients with dysphagia. This has encouraged both academia and industry to generate new orally disintegrating formulations and technological approaches in this field. ODTs are an economical method of drug delivery. ODTs are very important drug delivery system in cases where drug absorbed from buccal cavity. Various scientific techniques including spray drying, sublimation, freeze drying, molding, direct compression etc. have been employed for the development of ODTs. Today, ODTs are more widely available as over the counter products for the treatment of numerous diseases. The aim of this article is to review the advantages, limitations, formulation challenges, manufacturing techniques, patented technologies, marketed formulations and evaluation tests of ODTs. Keywords: Orally disintegrating tablets, Oral dosage form , Novel technique,