Objective & Scope: To evaluate the hypolipidemic activity of ethanolic extract of leaves of Moringa concanensisnimmo in guinea pigs Methods: 48 Guinea pigs of either gender were randomly divided into 6 groups. Hyperlipidemia was produced by giving cholesterol powder (500 mg/kg) for 60 days. Rosuvastatin 1.5 mg/kg served as active control group. While Moringa was given as 200 mg/kg for 30 days as preventive and curative groups for 0 to 30 days and 31 to 60 days respectively. Distilled water with normal diet for 30 dys was served as Normal control group. The preventive and curative effect of ethanolic extract of Moringa were assessed by serological and histopathological parameter. Results: Cholesterol administration produced increased level of Lipidsand liver enzymes along with histopathological alteration of liver andthoracic aorta. Preventive and therapeutic administration of 200 mg/kg ethanolic extract of Moringa resulted into a significant decrease of lipid profile and restoration of histopathological architecture of liver and thorasic aorta as compared to disease control group. Conclusion: Because of antioxidant properties, curative and preventive administration200 mg/kg ethanolic extract of Moringa exerts lipid lowering effect and can be used to treat and prevent dyslipidemia.