Entrepreneurship is the act of being an entrepreneur or one who undertakes innovations, finance and business acumen in an effort to transform innovations into economic goods. This paper draws women entrepreneurs in family business, and then identifies & addresses operational problems and challenges faced by women entrepreneurs in family business and how to mitigate those factors. Entrepreneurship is the state of mind which every woman has in her but has not been capitalized in India in a way it should be. Family Businesses are the most successful business enterprises all over the world and women’s contribution to the economy in every country is significant. Usually women do not have formal roles or titles in family business and their efforts are often unrecognized. Unfortunately, little research has been conducted on family-owned firms headed by women. As boundaries between business and family tends to be unclear, women operating family businesses face a unique set of issues related to personal identity, role conflicts, loyalties and family relationships. Although, many of the earlier barriers to women's business success have been removed, yet some still remain. This study is based on information obtained from survey which includes 100 Middle Class female respondents who have their family business but are not a part of their family businesses. Final analysis of the paper includes the challenges faced by women to enter into family business and the parameters essentially required to run a family business with their ranking.