This dataset is associated with the following publication, where further details are provided and which should be cited for further applications: Huang et al. 2022, Non-linear response of temperature-related mortality risk to global warming in England and Wales, Environ. Res. Lett., https://doi.org/10.1088/1748-9326/ac50d5. The data contain daily temperature-related mortality estimates for ten NUTS 1 regions of England and Wales over the period 1900 to 2099, based on temperatures from the 2018 UK Climate Projections (UKCP18) simulations. Exposure-response relationships are based on present-day observations and extrapolated where necessary. Variables in the csv files are as follows: "tmean": daily mean temperature (in degrees C) "bAD": backward attributable deaths "fAD": forward attributable deaths RCP 8.5 and RCP 2.6 scenarios are considered, as indicated in the file names. Model numbers refer to UKCP18 climate models.