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Submodular Selection of Assays v0.1

Authors: Wei, Kai; Libbrecht, Maxwell; Bilmes, Jeffrey A; Noble, William S;

Submodular Selection of Assays v0.1

Abstract

Submodular-Selection-of-Assays (SSA) Please see the following manuscript for more details: Kai Wei * , Maxwell W. Libbrecht * , Jeffrey A Bilmes, William S. Noble. "Evaluation and selection of panels of genomics assays." Submitted. Get the most recent version on github: https://github.com/melodi-lab/Submodular-Selection-of-Assays Abstract: Due to the high cost of sequencing-based genomics assays such as ChIP-seq and DNase-seq, epigenomic characterization of a cell type is typically carried out using a small panel of assay types. Deciding a priori which assays to perform is thus a critical step in many studies. We present submodular selection of assays (SSA), a method for choosing a diverse panel of genomic assays that leverages methods from the field of submodular optimization. More generally, this application serves as a model for how submodular optimization can be applied to other discrete problems in biology.

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Keywords

submodular optimization, epigenomics, genomics, high-throughput sequencing, discrete optimization

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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