Chemistry Department, Lucknow University, Lucknow-226 007 Virology Laboratory, Department of Botany, Lucknow University, Lucknow-226 007 Manuscript received 6 August 1986, revised 29 September 1988, accepted 9 March 1989 Some new derivatives of 5, 6-diphenyl-1,2,4-triazine-3-hydrazines ( 3a -p) were prepared by the condensation of 5,6-diphenyl-1,2,4-triazine-3-hydrazine (2 with substi-tuted-aldehydes, acetophenones, isatins and phenyl isothiocyanates. The condensation products were screened for their antiviral activity