Worldwide emergence of antimicrobial resistance among zoonotic pathogens imposes a need for an alternative approach to antibacterial therapy. The aim of this study was to evaluate activity of raw garlic extract against locally isolated serotypes of Salmonella Enteritidis and Staphylococcus aureus. For this purpose, standard antibiogram method was used. Results showed high efficacy of full garlic concentration, except in the case of one isolate of S. aureus, and varying efficacy of half extract doses, which was higher for S. aureus than for S Enteritidis.