3 to 5% of pregnancies are complicated by pre-eclampsia, which remains one of the main causes of fetal-maternal mortality and morbidity worldwide. The rate is higher in Morocco where the lack of prenatal consultation explains why pre-eclampsia is diagnosed at advanced stages. It is also responsible for 10 to 15% of maternal deaths in the Western world, and it remains the second leading cause of maternal death in France after the hemorrhage during delivery. Severe early pre-eclampsia (before 32 weeks of pregnancy) is associated with a risk of maternal mortality 20 times higher than after 37 weeks, and a higher risk of perinatal complications: prematurity, intrauterine growth retardation, premature detachment of the normoinsere placenta and perinatal mortality [3].Its pathophysiology is complex and multifactorial. The identification of biochemical and biophysical markers that point to placental and endothelial dysfunction allows us to improve our practices through new screening tests (4), which make it possible to target at-risk pregnancies, and to initiate treatment early. Currently, the coexistence of arterial hypertension, proteinuria and edema is arbitrary and inconstant. Preeclampsia can occurwithout the clinical data mentioned above or appear before the second half of pregnancy. Its symptoms are variable and reflect multisystem dysfunction [3]. Its development is unpredictable and can be overwhelming. The objective of this article is to report a case of atypical preeclampsia (before week 20 of gestation) associated with a HELLP Syndrome then to analyze the clinical features of atypical forms, differential diagnosis and progress in biochemical markers and biophysics that can aid in diagnosis.