Huisgen’s Cycloaddition Reactions: A Full Perspective

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jul 2016 English Publisher:Bentham Science Publishers Ltd.Journal:Current Organic Chemistry, volume 20, pages 1,591-1,647 (issn: 1385-2728,

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Authors: M.Heravi, Majid; Tamimi, Mehrnoush; Yahyavi, Hoda; Hosseinnejad, Tayebeh;

doi: 10.2174/1385272820666151217183010 , 10.6084/m9.figshare.19072535 , 10.6084/m9.figshare.19072535.v1 , 10.5281/zenodo.5913845 , 10.5281/zenodo.5913844

Huisgen’s Cycloaddition Reactions: A Full Perspective

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Abstract

Huisgen cycloaddition reaction has been originally utilized for the synthesis of 1, 2, 3-triazoles regioisomers. In this review, its stereochemistry and also mechanistical features of Huisgen cycloaddition reaction based on the quantum chemistry are highlighted. Thermal and copper catalyzed approaches to the synthesis of 1,2,3- triazoles will also be re-visited. Finally, the synthesis of alternative region-isomer, 1,5-disubstituted-1,2,3-triazoles under ruthenium catalysis and transition metal free conditions is described.

Related Organizations

Alzahra University
Iran (Islamic Republic of)

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