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Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

Authors: Bloom, Seth M; Kwon, Douglas S;

Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

Abstract

Compressed directories containing code and data files sufficient to reproduce analysis from Bloom et al paper on Lactobacillus iners (Nature Microbiology). An earlier, non-peer-reviewed manuscript version containing largely the same analysis was posted as a pre-print in bioRxiv at (https://doi.org/10.1101/2021.06.12.448098). Three compressed directory for analyses of: Vaginal Lactobacillus genome catalog characterization and gene content analysis. Analysis of relationship between cervicovaginal microbiota composition and cysteine concentrations in vaginal fluid from a South African cohort Analysis of results of in vitro mixed culture competition assays including: Pairwise competition between L. iners and Lactobacillus crispatus in Lactobacillus MRS broth containing L-cysteine +/- S-methyl-L-cysteine (SMC) Defined bacterial-vaginosis (BV)-like communities including L. iners, L. crispatus, and BV-associated species Gardnerella vaginalis, Prevotella bivia, and Atopobium (Fannyhessea) vaginae cultured in S-broth with or without SMC and/or metronidazole.

Keywords

Cysteine, Bacterial vaginosis, Cervicovaginal microbiota, Lactobacillus crispatus, Lactobacillus iners

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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