Background:Antibioticsare one of the most commonly used drugs in hospitalised patients and are sometimes associated with significant safety concerns. However, there is still insufficient data about the incidence of adverse drug reactions(ADR) especially in case of injectable antibiotics. This study was done to assess the severity and pattern of different types of adverse drug reaction that occurs with commonly used injectable antibiotics. Method: A retrospective cross-sectional study was done at Pharmacovigilance centre RIMS utilizing data from January 2018 till December 2019. Result: A total of 146patients who presented with antibiotic associated ADR reported during the study period were included in this study. Incidence was higher in males (90) as compared to females (56). The most common injectableantibiotic responsible for ADR was found to be the cephalosporin group (42.6%). A total of 178 different ADRs were observed among 146 patients, out of which the dermatological system (27.4%) was the most commonly affected system. On evaluation of WHO-UMC causality assessment of ADRs, majority were found to be possible (64.4%). Conclusion:Injectable antibioticsare one of the most importantdrugs used for treatment of various clinical conditions and the sheer magnitude of their usage among hospitalised patientsrequires special monitoring especially with respect to the adverse reactions they can cause.A more active pharmacovigilance is needed for better understanding of the types of injectable antibiotics associated ADRs. Active monitoring can also help promoterational use of these important life saving drugs.