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Article . 2003
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Synthesis and antimicrobial screening of cyclohexenones and oxazines

Authors: Jaladhi A; Vasavada; H. H. Parekh;

Synthesis and antimicrobial screening of cyclohexenones and oxazines

Abstract

Department of Chemistry. Saurashtra University. Rajkot-360 005, India E-mail: hhparekh@yahoo.com Fax : 91-0281-78512 Manuscript received 1 February 2002. accepted 21 August 2002 4-Cinnamoyloxybenzylidene (1) on condensation with various ketones yielded 1-aryl-3-(4'-cinnamoyloxypheny1)-2-propene-1-ones (2), which on cyclization with ethyl acetoacetate in acetone and urea in alcoholic KOH furnished 6-carbethoxy-5-(4'-cinnamoyloxypheny1)- 3-aryl-1-cyclohexenones (3a-h) and 2-imino-4-aryl-6-(4'-cinnamoyloxyphenyl)-6H-2,3-dihydro-1,3-oxazines (4a-h), respectively. All the compounds were screened for their antimicrobial activity.

Keywords

Cyclohexenones, zone of inhibition, Antimicrobial activity

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