Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China E-mail: bswan@dicp.ac.cn Fax: 86-411-84379260 Manuscript received 11 February 2003, revised 12 August 2003, accepted 4 September 2003 A pyridine-containing pyrethroid library of 255 compounds was conveniently constructed using parallel synthesis. The library was screened by high through-put screening (HTS), and further study was focused on the compounds with initial bioactivities. The results suggest that some compounds could be potential herbicides.