Department of Chemistry, Punjabi University, Patiala-147 002, Punjab, India E-mail: j_sandhu2002@yahoo.com Manuscript received 28 May 2007, revised 17 July 2007, accepted 18 July 2007 Recent advances In Biginelli reaction are summarized including its latest mechanism, developments In building blocks, catalysts variations, optimization/acceleration of reaction rate using various techniques like microwave irradiation and sonication etc. Also discussed is the reactivity of Biginelli scaffold and some of its modification with a brief note about its outlook.