Wikipedia is regarded as one of the most important channels for the public communication of science; English Wikipedia has around 1,500 articles relating to computational biology, which are frequently accessed as an educational resource. Joint efforts between the International Society for Computational Biology (ISCB) and the Computational Biology taskforce of WikiProject Molecular Biology (a group of expert Wikipedia editors) have considerably improved computational biology representation on Wikipedia in recent years. However, there is still an urgent need for further quality improvement, primarily while comparing to related scientific fields such as genetics and medicine. Facilitating the involvement of members from ISCB COSIs (Communities of Special Interest) would improve a vital open educational resource in computational biology, additionally allowing COSIs to provide a quality educational resource particular to their subfield. This first version of the COSI-Article matrix is a binary matrix identifying relevant ISCB COSIs for all Wikipedia articles relating to computational biology, defining a domain-specific open educational resource for each COSI. In addition, quality and importance ratings for each article allow identification of areas where domain experts could improve computational biology representation.