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This archive contains example files, data and models to run deepC predictions of chromatin interactions from DNA sequence, specifically the tutorials and example commands described in the deepC repository. https://github.com/rschwess/deepC https://github.com/rschwess/deepHaem Copies of the deepC and deepHaem cover are included for continuity. Please see the deepC publication for details: Schwessinger, R., Gosden, M., Downes, D. et al. DeepC: predicting 3D genome folding using megabase-scale transfer learning. Nat Methods 17, 1118–1124 (2020). https://doi.org/10.1038/s41592-020-0960-3 Human Hi-C is based on Rao, S. S. P. et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665–1680 (2014). Mouse Hi-C is based on Bonev, B. et al. Multiscale 3D genome rewiring during mouse neural development. Cell 171, 557–572.e24 (2017). DNase-seq and CTCF ChIP-seq were retrieved from the ENCODE Data portal (https://www.encodeproject.org/) Bernstein, B. E. et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57–74 (2012).
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