Raw data associated to the following publication: “Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism". The stress-responsive FKBP51 controls body weight gain by regulating the balance between autophagy and mTOR signaling. We identified FKBP51 as a central nexus for the recruitment of the LKB1/AMPK complex to WIPI4 and TSC2 to WIPI3, thereby regulating the balance between autophagy and mTOR signaling in response to metabolic challenges. MBH FKBP51 dose-dependently regulates autophagy both in the brain as well as in peripheral metabolic tissues. Consequently, deletion of MBH FKBP51 strongly induces obesity, while its overexpression protects against high-fat diet (HFD) induced obesity. IC data in Thermo RAW data format; 2nd of 2 datasets.

This work was supported by the "OptiMD" grant of the Federal Ministry of Education and Research (01EE1401D; M.V.S.), the BioM M4 award "PROCERA" of the Bavarian State Ministry (M.V.S.), the "GUTMOM" grant of the Federal Ministry of Education and Research (01EA1805; M.V.S.). and the "Kids2Health" grant of the Federal Ministry of Education and Research (01GL1743C; M.V.S.)