The Italian peninsula and the Tyrrhenian Sea are some of the geologically most complex regions on Earth. Such a complexity is expressed by large lateral and vertical variations of the physical properties as inferred from the lithosphere-asthenosphere structure and by the wide varieties of Plio-Quaternary magmatic rocks ranging from tholeiitic to calcalkaline to sodium- and potassium- alkaline and ultra-alkaline compositions. The integration of geophysical, petrological and geochemical data allows us to recognise various sectors in the Tyrrhenian Sea and surrounding areas and compare different volcanic complexes in order to better constrain the regional geodynamics. A thin crust overlying a soft mantle (10% of partial melting) is typical of the back arc volcanism of the central Tyrrhenian Sea (MAGNAGHI, VAVILOV & MARSILI) where tholeiitic rocks dominate. Similar lithosphere-asthenosphere structure is observed for Ustica, Vulture and Etna volcanoes where the geochemical signatures could be related to the contamination of the side intraplate mantle by material coming from either ancient or active roll-back. The lithosphere-asthenosphere structure and geochemical-isotopic composition do not change significantly when we move to the Stromboli-Campanian volcanoes, where we identify a well developed low-velocity layer, about 10-15 km thick, below a thin lid, overlain by a thin continental crust. The geochemical signature of the nearby Ischia volcano is characteristic of the Campanian sector and the relative lithosphere-asthenosphere structure may likely represent a transition to the back arc volcanism sector acting in the central Tyrrhenian. The difference in terms of structure beneath Stromboli and the nearby Vulcano and Lipari is confirmed by different geochemical signatures. The affinity between Vulcano, Lipari and Etna could be explained by their common position along the Tindari-Letoianni-Malta fault zone. A low velocity mantle wedge, just below the Moho, is present in all the regions related to the inactive recent volcanoes (Amiata, Vulsini, & Cimino, Vico, Sabatini, Albani Hills) in the Tuscany and Roman regions. A very thick rigid body is found in the upper mantle beneath the Ernici-Roccamonfina province that exhibits very distinct geochemical and isotopic compositions when compared with the Roman province.