The study aims to assess the acceptance or refusal to take the Novel Coronavirus Vaccine by the residence of Makkah city. The study was conducted online where the researchers made an electronic questionnaire distributed among the population, considering not to include those who have any ties with health sectors, pharmaceuticals, vaccine companies, or Local and international Food and Drug authorities. The researcher and his colleagues distributed the electronic questionnaire by phone, online contacts, and social networks. More than 1000 respondents (random sample) aged 16 and above from different backgrounds and neighborhoods were contacted within Makkah, and 450 responses were obtained due to the difficulties of conducting in-person interviews during social distance regulations. The responses were taken from those who had not previously been vaccinated.