The augmentation of regenerative capability is a powerful method for pursuing for the regulation of degeneration, traumatic injury and cancer. The tadpole, Clinotarsus curtipes and Xenopus laevis is a significant model system for addressing the fundamental regeneration mechanism that enables to understand the key aspects of regeneration medicine. The selected creatures Clinotarsus curtipes and Xenopus laevis could able to obtain both tissue regeneration and scar free healing during larval stage in spite of its predominant loss of such ability during the metamorphic process. Such transient capability associated with the evolutionary correlation with humans creates Clinotarsus curtipes and Xenopus a very good attractive model for uncovering the functional regeneration mechanisms. The study analysed the existing literatures on change in the levels of ROS that is required for the proper wnt-signaling in every regeneration system. Apart from that the paper provided the comprehensive review on the histopathological view, regeneration signals like TGFβ, FGF, BMP, Wnt etc for successful regeneration. Factors that affect the tail regeneration like O2 influx, epigenetics and HDAC activity have also been provided. Significant other such criteria like role of TRKA signaling, profiling and intracellular protein expression followed by its corresponding challenges adds value to the paper.The study presents an overview of Xenopus and Clinotarsus curtipesas a model organism for the research and highlighted the new insights.