Hypertrophic cardiomyopathy (HCM), which is the most common genetic cardiac disease, is diagnosed by the presence of ventricular hypertrophy in the absence of any abnormal loading conditions causing it. Clinical manifestations of HCM are highly variable—individuals with HCM can either be asymptomatic or exhibit dyspnea, fatigue, palpitations, chest pain, sudden cardiac death, cardiac arrhythmias, or heart failure. The HCM Clinical contains knowledge elements on the clinical aspects of HCM, including genetic differential diagnosis, clinical diagnosis and monitoring, and treatment. The elements incorporated are in line with the HCM clinical practice guidelines. The HCM Clinical was built using CellDesigner v. 4.4.2, and the annotations for all the components were added using the Minimal Information Requested In the Annotations of Models (MIRIAM). The HCM Clinical was converted into an interactive HCM knowledge resource and made publicly available using the Molecular Interaction NEtwoRks VisuAlization (MINERVA) platform v. 15.1.2. The HCM Clinical will be continuously updated with information from the HCM clinical guidelines and research community regarding HCM diagnosis, monitoring, and treatment improvements. The HCM Clinical interactive knowledge resource is available at: https://silicofcm.eu/hcm-clinical-interactive/.