The CADRE Five Safes framework is an output of the CADRE (Coordinated Access for Researchers, Data and Environments) Platform project. The CADRE framework includes the conceptual underpinnings and the guardrails for sensitive data access management and the range of information associated with the Five Safes principles that can be operationalised in a decision-support system. In the Introduction and Context sections the CADRE Platform project and the social science research data management practices associated with sensitive quantitative and qualitative data are outlined. In the Conceptualisation section a full exploration is undertaken of: the uptake of Five Safes framework in Australia; the concepts from the Five Safes framework i.e., projects, people, data, settings and outputs; additional concepts i.e., organisations and groups; and key intersections and alignments of these concepts. In the Operationalisation section the information requirements associated with managing sensitive data access requests and provisioning research environment services for sensitive data analysis are evaluated and initial information and data models are proposed for the CADRE information exchange. In the Appendices the user requirements from project partners helping to develop the CADRE Platform are summarised and sensitive data categorisations are collated.