This paper presents an integrated approach to evaluate gating system configurations to optimize the filling conditions of thermoplastic injection moulded parts. Through data integration between the finite element (FE) analysis and the Design of Experiment approach, the filling of parts with complex geometries was studied to optimize injection process parameters and improve the product quality. The numerical simulation of an injection moulding process allows the evaluation of the component manufacturability at the early stage of the development cycle, without fabricating prototypes and minimizing experimental tests. Normally, the FE analysis interests concerns filling, post-filling and cooling phases of the injection process, the simulation will presents the hot runner gating system design of multi cavity mould. The main challenge is to design and produce a mold that is straightforward to manufacture, while providing uniform filling and cooling of plastic parts. The basic model was used to compare with the updated finite element model representing the real structure. The FE model presented an average of 40% control in damage of hot runner nozzle than the real hot runner nozzle.