Present research focus on design and analysis of silicon and stainless steel based hollow micro-needles for transdermal drug delivery (TDD) has been presented. By using ANSYS &CFD (computational fluid dynamic), structural and micro fluidic analysis has been performed to ensure that the micro-needles design suitability for Drug delivery. The effect of axial and transverse load on single and micro-needle array has been investigated & the mechanical properties of micro-needle. The analysis predicts that the resultant stresses due to applied bending and axial loads are in the safe & comfort desired range. In computational fluid dynamic (CFD) static analysis, the fluid flow rate through micro-needle array was investigated by applying the pressure in the inlet the micro-needles were capable for flow of drug up to the desired range. Towards achieving painless injections and other micro fluidic applications, the work was focused on the conically tapered hollow needles of micron dimensions. The relationship between pressure drop and flow rate through micro-needles was analyzed quantified as a function of fluid viscosity, micro-needle length, diameter and cone half-angle. The dimensionless pressure drop sharply decreased as the indicating role of viscous forces on the boundaries of the micro-needles increased. The flow was almost in viscid, indicates that the effect of pressure drop, numerical simulations showed that the flow through conically tapered micro-needles was mainly controlled by the diameter and taper angle of the micro-needle tip. The hollow out-of-plane micro-needle of micron sized devices for drug delivery applications was investigated.