In this review article, there is a collection of evidence that describes the myths and facts regarding intermittent fasting (IF). Fasting is an age­ old practice, often done for religious reasons, but fasting for weight loss is still capturing the public imagination. Intermittent fasting and Calories restriction (CR) is worldwide popular in men and women of all ages, it has become fitness trend to help them maintain healthand lose weight. It also has positive as well as negative impacts on metabolic activities. There are potential researches that analyze IF and CR as beneficial for Weight loss, Cardiovascular diseases, Cancer, Cognitive, Type 2 diabetes, and reduce Oxidative stress. Similarly, there are some facts and myths that are related to IF and CR which are worth knowing.