This database includes the raw data linked with the paper “Twenty-four hour blood pressure profile in idiopathic REM sleep behaviour disorder ” published on “Sleep”. The paper aimed to evaluate 24-hour blood pressure (BP) control in iRBD. 24-hour ambulatory BP monitoring was performed in in 21 iRBD, 21 drug-free de novo Parkinson's disease (PD) subjects and 21 control subjects (HCs). A prospective follow-up study was performed to evaluate the occurrence of neurodegenerative disorders in the iRBD cohort. In the iRBD group, night-time systolic BP (SBP) was higher, nocturnal BP decrease lower and non-dipping status more frequent than in the HCs. Patients with PD showed daytime and night-time BP profiles comparable to those observed in iRBD. A sub-group analysis considering only the subjects without antihypertensive therapy (12 iRBD, 12 PD) showed results superimposable on those of the whole iRBD and PD groups. Longitudinal follow up showed no differences in BP profile at baseline between converters and non-converters.