Department of Pharmacy, Vikas Group of Institution, Nunna-521 212, Vijayawada Rural, Andhra Pradesh, India E-mail: drbiswamohansahoo@gmail.com Community Health System of South Texas, Edinburg, Texas 78539, USA Pharmacy Wing, SCB Medical College, Cuttack-753 007, Odisha, India Manuscript received 28 September 2018, accepted 01 November 2018 In the present study, microwave-mediated Green chemistry approach is followed to prepare some chalcone derivatives. For this purpose, microwave heating technology is used as the alternative energy sources to synthesize a series of chalcone de­rivatives by Claisen-Schmidt condensation of ethyl 4-acetamidobenzoate with various aromatic aldehydes in the presence of ethanolic sodium hydroxide solution followed by dehydration. With the help of microwave, the rate of reaction is increased with less byproduct formation and better yield of the product. The structures of the newly synthesized compounds are con­firmed by FT-IR, 1H NMR, mass spectra and CHN analyses. The titled compounds are screened for their anthelmintic activity and significant activity as compared to the standard drug is found. Compounds with electron withdrawing groups are found to be highly potent among the series.