Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Odisha, India Department of Pharmacy, Vikas Group of Institution, Vijayawada-521 212, Andhra Pradesh, India Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: jrpanda77@gmail.com, drbiswamohansahoo@gmail.com Manuscript received 28 September 2018, accepted 01 November 2018 An efficient method is developed and exploited for the synthesis of indole derivatives via microwave-assisted technology. By considering the advantage microwave synthesis in terms of high efficient energy, indole derivatives are prepared. In the current study, the Schiff’s bases are first synthesized by reaction of 1H-indole-2,3-dione (isatin) with various substituted anilines in presence of acetic acid under microwave irradiation. Then the Mannich bases are produced by condensation of Schiff bases with different secondary amines in the presence of formaldehyde. The newly synthesized compounds are characterized by TLC report and spectral data followed by evaluation for anthelmintic activity against Pheretima posthuma. Albendazole is used as standard drug for comparative study. The titled compounds are screened for anthelmintic activity at the concentration of 10, 20 and 50 mg/ml. The anthelmintic effect of standard drug Albendazole is also evaluated at 10 mg/ml. The results of present study indicate that some of the tested compounds exhibit significant anthelmintic activity in dose dependent manner.