According to various studies, stress is the major problem for many dangerous diseases ranging from psychiatric disorders to endocrine disorders including diabetes mellitus, hypothyroidism, peptic ulcers, male sexual dysfunction, ulcerative colitis, hypertension etc. Today���s lifestyle was very frustrated due to busy schedule of even school going child up to old aged people. That is the reason medication identified with pressure and psychosis has a tremendous market on the planet. Usage of modern medicine has some benefits &results but they are mixed and unsatisfactory. Recent studies shows that the ayurvedic herbs having adaptogens which could induce the state of non-specific increase in resistance to affect internal homeostasis. The adaptogens improves the stress response and helps the body to adopt by normalizing physiological processes in times of increased stress .Alternanthera sessilis is one of the best phytomedicine for anti-stress activity. It is commonly known as sessile joy weed. Imbalance between the reactive oxygen species (ROS)leads to the generation of oxidative stress in our body. The anti-oxidant nature of this plant shows a promising relief from all kinds of stress. The anti-stress activity of ethanolic extract of Alternanthera sessilis was evaluated by using in vivo methods like forced swim test (FST), Tail suspension test(TST),Open field test (OFT),Learned vulnerability test, Gastric ulceration test. Conclusion- This study shows promising relief from stress due to the anti-oxidant nature of Alternanthera sessilis.