The dataset contains the upper-limb kinematics collected in 40 participants before and after a short-term immobilization of the right arm. Three reach-to-grasp movements were required, targeting an object placed a) frontally at the level of the shoulders (A_low), b) frontally above the head (A_high), or c) laterally at the level of the shoulders (L_low). These movements were intended to test different degrees of freedom of the shoulder joint. Half of the participants underwent a virtual-reality action observation treatment (see Rizzolatti et al, Neuroscience and Biobehabioral Reviews, 2021), while the control group underwent a non-motor VR stimulation.