{"references": ["Hazenberg BP, Amyloidosis: a clinical overview, Volume 39, Issue 2, Rheumatic diseases clinics of North America, Elsevier, 2013", "Falk RH, Alexander KM, Liao R, Dorbala S, AL (Light-Chain) Cardiac Amyloidosis: A review of Diagnosis and Therapy, Volume 68, Issue 12, Journal of the American College of Cardiology, Elsevier, 2016", "Trinn C., Amyloidosis, Volume 151, Issue 29, AK Journals, Orvosi Hetilap, 2010", "Philippakis A, Falk RH, Cardiac Amyloidosis Mimicking Hypertrophic Cardiomyopathy with obstruction: Treatment with Disopyramide, Volume 125, Issue 14, Circulation, AHA Journals, 2012", "Mohty D, Damy T, Cosnay P, Echahidi N, Cardiac Amyloidosis: Updates in diagnosis and management, Volume 106, Issue 10, Archives of Cardiovascular Diseases, Elsevier, 2013", "Holmes RO, Edison J, Baethge B, Jacobson D, Amyloidosis, Medscape, 2021", "Ihne S, Morbach C, Sommer C, Geier A, Knop S, St\u00f6rk S, Amyloidosis\u2014the Diagnosis of an Underdiagnosed Disease, Volume 117, Issue 10, Deutsches \u00c4rzteblatt International, 2020", "Merlini G, Seldin D, Gertz M, Amyloidosis: Pathogenesis and New Therapeutic Options, Volume 14, Issue 29, Journal of Clinical Oncology, 2011"]}

Amyloidosis is a heterogeneous group of diseases, in which one or more organs are infiltrated by extracellular proteinaceous deposits, known as amyloid. These deposits aggregates in the form of insoluble fibrils. The prognosis of the disease is determined both by the organ(s) involved and the type of the amyloid. Except of the brain other organs can be affected too: kidney, liver, spleen, lung, gastrointestinal tract, endocrine organs, skin and heart. In its early stages, amyloidosis might not cause symptoms. When it becomes more severe, which symptoms you have depend on the organ or organs that are affected. Amyloidosis is divided into systemic and localized or acquired and hereditary. The 4 main types of systemic amyloidosis are: a) primary or Amyloid Light-chain (AL) amyloidosis, b) secondary or disorder of A chains amyloidosis (AA, which frequently appears in combination with inflammatory diseases), c) Amyloid Transthyretin (ATTR) amyloidosis and d) Amyloid Beta 2-microglobulin (Aβ2M) amyloidosis, associated with dialysis.