In this SIENNA deliverable we present five general methods for translating ethical analysis into frameworks and methods for the ethical guidance of new emerging technologies. These are: a multistakeholder, coevolutionary strategy for ethically responsible development, deployment and use of new technology, a step-by-step method for the development of ethics guidelines and ways in which guidelines can be operationalized, a general approach for Ethics by Design, that works for all technology fields, suggestions for ethics and human rights projects on new and emerging technologies for engaging with policy-maker, and finally a method on how research ethics committees can support ethics in new emerging technology research.